文波 （复旦大学生物医学研究院研究员）

人物经历

教育经历

工作经历

2005年起在约翰。霍普金斯大学医学系及表观遗传学中心从事博士后研究，

并于2009年晋升为讲师(Instructor)。

2010年被聘为复旦大学生物医学研究院研究员。

2010年入选上海曙光计划项目。

科研成就

研究方向

1.以多能干细胞定向分化、精子发生为模型研究细胞身份转换的表观遗传机制。

2.长非编码RNA（LncRNA）与染色质相互作用机制。

论文

在Nature、Nature Genetics、American Journal of Human Genetics、Genome Research 等国际学术期刊上发表论文20余篇，被引2800多次。

1.Wen B, Wu H, Loh YH, Briem E, Daley GQ, Feinberg AP*. Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions. BMC Genomics. 2012; 13:566.

2.Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ*. Epigenetic memory in induced pluripotent stem cells.  Nature 2010 ;16 (7313):285-90.

3.Wen B, Wu H, Shinkai Y, Irizarry R and Feinberg AP*.  Large histone H3 lysine-9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nature Genetics  2009;41: 246-50.

4.Doi A, Park IH, Wen B, Murakami P, Aryee M, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ and Feinberg AP*.  Differential methylation of tissue- and cancer specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 2009; 41(12):1350-3.

5.Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP*.  The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nature Genetics  2009; 41:178-186.

6.Wen B, Wu H, Bjornsson H, Green RD, Irizarry R, Feinberg AP.  Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification. Genome Research  2008; 18:1806-13.

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