研究领域
系统生物学,基于网络动态的重大疾病机理研究及生物标记物研发。
承担科研项目情况:
“百人计划”2013-2015
国家自然科学基金委面上项目, 2013-2016年,80万
上海市科学技术委员会重点专项,2013-2015, 310万
代表论著
1. Chang H, Liu Y, Xue M, Liu H, Du S, Zhang L, et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic acids research 2016, 44(6): 2514-2527.
2. Li L, Wang D, Xue M, Mi X, Liang Y, Wang P. 3'UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network. Scientific reports 2014, 4: 5406.
3. Wang L, Hu X, Wang P, Shao ZM. The 3'UTR signature defines a highly metastatic subgroup of triple-negative breast cancer. Oncotarget 2016.
4. Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H: Transcriptional reprogramming of mature CD4? helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. (Nat Immunol. 2013 14(3):281-9).
5. Chen C, Dow C, Wang P, Sidney J, Read A, Harmsen AG, Samuel JE, Peters B: Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. 2011. (PLoS One, 2011 Mar15;6(3):e17712)
6. Wang P, Sidney J, Sette A, Peters B: Peptide binding predictions for all HLA class II loci. 2010. (BMC Bioinformatics. 2010; 11: 568)
7. Zhang H, Wang P, Papangelopoulos N, Xu Y, Sette A, Bourne PE, Lund O, Ponomarenko J, Nielsen M, Peters B: Limitations of ab initio predictions of peptide binding to MHC class II molecules. PLoS One. 2010, 5(2):e9272. (co-first author)
8. Wang P, Sidney J, Dow C, Mothe B, Sette A, Peters B: A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol 2008, 4(4):e1000048.
9. Wang P, Yan B, Guo JT, Hicks C, Xu Y: Structural genomics analysis of alternative splicing and application to isoform structure modeling. Proc Natl Acad Sci U S A 2005, 102(52):18920-18925.