袁林 （湖南大学化学化工学院教授）

人物简介

1982年出生于湖南新邵。2006年于南华大学获工学学士学位。2013年于湖南大学获化学博士学位。2014年2月至-2015年3月在新加坡国立大学化学系从事化学生物学方向博士后研究。2012年6月加入湖南大学，2015年10月起任副教授，2017年1月起任教授。曾获教育部博士研究生学术新人奖，湖南省优秀博士学位论文。近5年发表通讯或第一作者SCI源刊论文32篇，单篇最高他引超过420次，7篇论文他引超过100次的，其中影响因子>5.0的论文23篇，包括J. Am. Chem. Soc. 5篇，Angew. Chem. Int. Ed. 5篇，Chem. Sci. 1篇，Anal. Chem. 1篇，Adv. Funct. Mater 1篇，Biomaterials 2篇等。曾主持国家自然科学基金青年项目，湖南省自然科学基金面上项目等项目；2016年获国家优秀青年科学基金资助。

人物经历

教育经历

2002.9-2006.7 南华大学化学化工学院，工学学士。

2006.9-2008.8 湖南大学化学化工学院，无。

2008.9-2013.5 湖南大学化学化工学院，理学博士。

工作经历

2012. 6-2015. 9 湖南大学化学化工学院，助理教授。

2014. 2-2015. 3 新加坡国立大学化学系，博士后。

2015. 10-2017. 1 湖南大学化学化工学院，副教授。

2017. 1- 现在 湖南大学化学化工学院，教授。

研究邻域

分子探针及生物成像、有机光功能染料合成及应用。

科研项目

国家自然科学基金优秀青年基金（2017-2019）

国家自然科学基金面上项目（2019-2022）

国家自然科学基金重点项目(子课题)（2018-2022）

湖湘青年英才项目（2017-2019）

Selected Publications: (Corresponding Author)

代表性论文

1、D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang.Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe.J. Am. Chem. Soc. 2017,139, 285-292.

2、J. Peng, A. Samanta, X. Zeng, S. Han, L. Wang, D. Su, D.T.B.Loong, N.-Y. Kang, S.-J. Park, A. H. All, W. Jiang, L. Yuan*, X. Liu*, Y.-T. Chang. Real-timeinvivohepatotoxicitymonitoringthroughchromophore-conjugatedupconversionnanoprobes. Angew. Chem. Int. Ed. 2017,Accepted.

3、W. Xu, Z. Zeng, J.-H. Jiang*, Y.-T.Chang*, L. Yuan*. Discerning the chemistry in individual organelles with small molecule fluorescent probes.Angew. Chem. Int. Ed. 2016,55, 13658-13699.

4、L. Wang, L. Yuan*, X. Zeng, J. Peng, Y. Ni, J. C. Er, W. Xu, B. K. Agrawalla, D. Su, B. Kim, Y.-T. Chang*. Amultisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells.Angew. Chem. Int. Ed. 2016,55, 1773-1776.

5、J. Peng, C. L. Teoh, X. Zeng, A. Samanta, L. Wang, W. Xu, D. Su, L. Yuan*, X. Liu, Y.-T. Chang*. Development of a highly selective, sensitive, and fast response upconversion luminescent platform for hydrogen sulfide detection.Adv. Funct. Mater. 2016,26, 191-199.

6、Y. Wei, D. Cheng, T. Ren, Y. Li, Z. Zeng, L. Yuan*. Design of NIR chromenylium–cyanine fluorophore library for “switch-on” and ratiometric detection of bio-active speciesin vivo.Anal. Chem. 2016,88, 1842−1849.

7、L. Yuan, L. Wang, K. Bikram, S.-J. Park, H. Zhu, B. Sivaraman, J. Peng, Q. Xu, Y.-T. Chang. Development of targetable two-photon fluorescent probes to image hypochlorous acid in mitochondria and lysosome in live cell and inflamed mouse model.J. Am. Chem.Soc. 2015, 137, 5930−5938.

8、L. Yuan*, F. Jin, Z. Zeng*, C. Liu, S. Luo, J. Wu. Engineering a FRET strategy to achieve a ratiometric two-photon fluorescence response with a large emission shift and its application to fluorescence imaging.Chem Sci, 2015,6, 2360-2365.

9、L. Yuan, W. Lin*, H. Chen, S. Zhu, L. He. A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging.Angew. Chem. Int. Ed. 2013,58,10018–10022.

10、L. Yuan, W. Lin*, L. Tan, K. Zheng, W. Huang. Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells.Angew. Chem. Int. Ed. 2013,52, 1628–1630.

11、L. Yuan, W. Lin*, K. Zheng, L. He, W. Huang, Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging.Chem. Soc. Rev., 2013,42, 622-661.

12、L. Yuan, W. Lin*, K. Zheng, S. Zhu, FRET-based small-molecule fluorescent probes: rational design and bioimaging applications.Acc. Chem. Res. 2013,46, 1462-1473.

13、L. Yuan, W. Lin, H. Chen, Analogs of Changsha near-infrared dyes with large Stokes Shifts for bioimaging.Biomaterials, 2013,34, 9566-9571.

14、L. Yuan, W. Lin*, S. Zhao, W. Gao, B. Chen, L. He, S. Zhu, A unique approach to development of near-infrared fluorescent sensors for in vivo imaging.J. Am. Chem.Soc. 2012,134, 13510-13523.

15、L. Yuan, W. Lin,* Y. Xie, B. Chen, S. Zhu.Single fluorescent probe responds to HO, NO, and HO/NO with three different sets of fluorescence Signals.J. Am. Chem. Soc.2012,134, 1305-1315.

16、L. Yuan, W. Lin,*Y. Yang, H. Chen. A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals.J. Am. Chem. Soc.2012,134,1200-1211.

17、D. Cheng, J. Peng, Y. Lv, D. Su, D. Liu, M. Chen, L. Yuan*, X. Zhang. De Novo Design of Chemical Stability Near-infrared Molecular Probes for High-fidelity Hepatotoxicity Evaluation in Vivo. J. Am. Chem. Soc. 2019, DOI: 10.1021/jacs.9b01374.

18、L. Su, T. Ren, J. Dong*, L. Liu, S. Xie, L. Yuan*, Y. Zhou*, SF. Yin. Cu (I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties. J. Am. Chem. Soc. 2019, 141 (6), 2535–2544. DOI: 10.1021/jacs.8b12495

19、T. Ren, W. Xu, W. Zhang, X. Zhang, Z. Wang, Z. Xiang, L. Yuan*, X. Zhang. A General Method to Increase Stokes Shift by Introducing Alternating Vibronic Structures. J. Am. Chem. Soc. 2018, 140 (24), 7716–7722. DOI: 10.1021/jacs.8b04404

20、T. Ren, W. Xu, Q. Zhang, X. Zhang, S. Wen, H. Yi, L. Yuan*, X. Zhang. Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network. Angew. Chem. Int. Ed. 2018, 57(25), 7473-7477. DOI:10.1002/anie.201800293

21、Y. Lv, D. Cheng, D. Su, M.Chen, B.-C. Yin, L. Yuan*, X. Zhang. Visualization of Oxidative Injury in the Mouse Kidney by Selective Superoxide Anion Fluorescent Probes. Chem. Sci., 2018, 9, 7606-7613. DOI:10.1039/C8SC03308K

20、T. Ren, Q. Zhang, D. Su, X. Zhang, L. Yuan*, X. Zhang. Detection of Analytes in Mitochondria without Interference from Other Sites Based on an Innovative Ratiometric Fluorophore. Chem Sci, 2018, 9, 5461-5466. DOI:10.1039/C8SC01673A

奖励荣誉

2017年，湖南青年英才。

2016年，国家优青。