林海燕 （中科院动物研究所副研究员）

简介

1997和2000年获北京师范大学学士和硕士学位。2005年获中国科学院动物研究所博士学位。2006年至2008年在加拿大温哥华不列颠哥伦比亚大学妇产科系做博士后，主要从事皮质醇结合球蛋白CBG（负责转运孕酮与皮质醇）基因转录调控和蛋白质功能研究。多年来一直从事胚胎植入、胎盘发育的分子机理研究，目前主要进行“CBG在人胎盘中的功能及其多态性与先兆子痫发病的关系”研究。主持国家自然科学基金面上项目、青年基金项目和中国科学院院长基金特别资助项目等。近几年间在J Biol Chem等期刊发表SCI收录论文32篇（第一作者/通讯作者10篇）。

研究领域

主要从事皮质醇结合球蛋白CBG（负责转运孕酮与皮质醇）基因转录调控和蛋白质功能研究。

代表论著

Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis

Zhang S, Lin HY (co-first author), Kong S (co-first author), Wang S, Wang Hongmei, Wang Haibin*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med

Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 2013, Feb 21 [Epub ahead of print].

Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS ONE

Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab

Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem

Li Y, Wu L, Lei JH, Zhu C, Wang H, Yu XG*, Lin HY*. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci,

Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA*. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS ONE

Wu L, Zhou HH, Lin HY, Qi JG, Zhu C, Gao ZY*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction

Yang XK, Zhou Y, Peng S, Wu L, Lin HY, Wang SY*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction

Lin HY*, Muller YA, Hammond GL*. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol

Fu J, Lv X, Lin HY, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem

Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL*. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem,

Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY*. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem

Zhang B, Zhou Z, Lin HY, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol

Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta

Zhang H, Lin HY, Yang Q, Wang HX, Chai KX, Chen LM, Zhu C*. Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy. J Histochem Cytochem,

Yang Q, Lin HY, Wang HX, Zhang H, Zhang XP, Wang H, Zhu C*. Expression of smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy. J Histochem Cytochem

Zhang X, Zhu C, Lin HY, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod

Zhang H, Li Q, Lin HY, Yang Q, Wang H, Zhu C*. Role of PPARgamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro. Neuroendocrinol Lett

Lin HY, Yang Q, Wang H, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C*. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-β1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci

Lin HY, Zhang H, Yang Q, Wang HX, Wang H, Chai KX, Chen LM*, Zhu C*. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. J Histochem Cytochem

Lin HY, Qian D, Zhang X, Liu GY, Wang H, Zhu C*. Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci

Wang HX, Wang H, Lin HY, Yang Q, Zhang H, Tsang BK, Zhu C*. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol

Liu GY, Zhang X, Lin HY, Wang H, Li QL, Ni J, Zhu C*. Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9. Biochem Biophys Res Commun

Yang Q, Wang HX, Zhao YG, Lin HY, Zhang H, Wang H, Sang QA, Zhu C*. Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sc

Zhang X, Lin HY, Liu GY, Wang H, Li QL, Zhu C*. Expressions and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy. Front Biosci

Wang HX, Zhao YG, Wang H, Yang Q, Lin HY, Sang QA, Zhu C*. Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Mol Hum Reprod,

Lin HY, Wang H, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C*. Expression of Smad2 and Smad4, transforming growth factor-β signal transducers, in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci

Qian D, Lin HY, Wang H, Zhang X, Liu DL, Li QL, Zhu C*. Normoxic induction of the hypoxic-inducible factor-1α by interleukin-1β involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells. Biol Reprod

Liu G, Lin HY, Zhang X, Li Q, Wang H, Qian D, Ni J, Zhu C*. Expression of Smad2 and Smad4 in mouse uterus during the estrous cycle and early pregnancy. Placenta

Qian D, Lin HY, Wang H, Zhang X, Li QL, Liu DL, Zhu C*. Involvement of ERK1/2 pathway in TGF-β1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev

Zhang X, Wang H, Lin HY, Liu GY, Li QL, Zhu C*. Regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) during mouse peri-implantation: role of nitric oxide. Placenta

Wang H, Zhang X, Qian D, Lin HY, Li QL, Liu DL, Liu GY, Yu XD, Zhu C*. Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9. Biol Reprod,

Wang HX, Wang H, Li QL, Lin HY, Qian D, Zhu C*. Expression of proteasome subunits LMP2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta)during early pregnancy. Biol Reprod

Lin HY, Wang H, Zhu C*. The Smad pathway in transforming growth factor-beta signaling. Sci China C Life Sci

Wang H, Li QL, Lin HY, Yu XD, Qian D, Dai JJ, Duan EK, Zhu C*. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Mol Reprod Dev,

Qian D, Wang H, Lin HY, Zhang X, Li QL, Liu DL, Liu GY, Zhu C*. Effect of UPP on the expression of VEGF and its receptors in mouse uterus during peri-implantation. Chin Sci Bull,

Li QL, Wang H, Lin HY, Zhu C*. Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Mol Reprod Dev

Liu DL, Li QL, Lin HY, Liu WZ, Wang H, Zhang X, Zhu C*. Expression and localization of RAP250 mRNA in the rat ovary: Possible implications in follicular development and ovulation. Endocrine

Li QL, Wang H, Lin HY, Shao LJ, Ni J, Duan EK, Zhu C*. Expression of VEGF in the pregnant and postpartrum rat ovaries. Sci China C Life Sci,

Zhang X, Wang H, Lin HY, Li QL, Liu DL, Qian D, Liu GY, Zhu C*. Regulation of blastocyst implantation by nitric oxide in mouse. Chin Sci Bul

Li QL, Wang H, Zhao YG, Lin HY, Sang QA, Zhu C*. Identification and specific expression of endometase/matrilysin-2 (MMP-26) in endometrium of rhesus monkey during early pregnancy. Mol Hum Reprod