吴强 （上海交通大学特聘教授）

人物经历

1990年复旦大学学士；

1993年分别获得复旦大学硕士；

1998年获美国纽约州立大学石溪分校和冷泉港实验室细胞发育生物学博士；

2002年，助理教授，博导；

2008年，特聘教授；

2018年，二级教授；

2020年，讲席教授。

主要成就

著作

Huang H. and Wu, Q*. (2010). Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity. PLoS ONE 5: E9144.

Ying,G., Wu, S., Hou, R., Huang, W., Capecchi, M., Wu, Q*. (2009). Protocadherin Celsr3 is required for interneuron migration in the mouse forebrain. Molecular and Cellular Biology 29:3045-3061.

Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2008). A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond. Nature Protocol 3:1056-1076.

Zou, C., Huang, W., Ying, G., and Wu, Q*. (2007). Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Neuroscience 144: 579-603.

Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2007). Towards simpler and faster genome-wide mutagenesis in mice. Nature Genetics 39: 922-930.

Li, C. and Wu, Q*. (2007). Evolution of vertebrate multiple variable first exons and structural diversity of drug metabolizing enzymes. BMC Evolutionary Biology 7: 69.

Wu, Q*#. (2005). Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics 169:2179-2188.

Zhang, T., Haws, P., and Wu, Q*. (2004) Multiple variable first exons: a mechanism for cell- and tissue- specific gene regulation. Genome Research 14: 70-89.

Tasic, B., Nabholz, C.E., Baldwin, K.K., Kim, Y., Rueckert, E.H., Ribich, S.A., Cramer, P., Wu, Q., Axel, R., and Maniatis T. (2002). Promoter choice determines splice site selection in protocadherin  and  pre-mRNA splicing. Mol. Cell 10: 21-33.

Wu, Q#., Zhang, T., Cheng, J.-F., Kim, Y., Grimwood, J., Schmutz, J., Dickson, M., Noonan, J.P., Zhang, M.Q., Myers, R.M., and Maniatis, T. (2001). Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research 11: 389-404.

Wu, Q#. and Maniatis, T. (2000). Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proc Natl Acad Sci USA 97:3124-3129.

Pohl U., Smith J.S., Tachibana I., Ueki K., Lee H.K., Ramaswamy S., Wu Q., Mohrenweiser H.W., Jenkins R.B., Louis D.N. (2000). EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Genomics 63: 255-262.

Wu, Q#. a   nd Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790.

Wu, Q#. and Krainer, A.R. (1999) AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Molecular and Cellular Biology 19: 3225-3236.

Wu, Q#. and Krainer, A.R. (1998) Purine-rich enhancers function in the AT-AC splicing pathway and do so independently of intact U1 snRNP. RNA 4: 1664-1673.

Wu, Q#. and Krainer, A.R. (1997) Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA 3: 586-601.

Wu, Q#. and Krainer, A.R. (1996) U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274: 1005-1008.