基本介绍
主要教育和工作经历：
1991-1995 武汉大学生命科学学院学士
1995-1998 武汉大学生命科学学院硕士
1998-2000 中国医学科学院基础医学研究所博士
2004-2005 Georgetown University 博士后
2000-2004 中国医学科学院基础医学研究所助理研究员，副研究员
2005-2008 Case Western Reserve University 研究助理
2008-至今武汉大学生命科学学院教授
主要任职、获奖及荣誉：
生命科学学院仪器设备共享中心主任
2011年获教育部“新世纪优秀人才计划”
中华预防医学会科学技术奖评审委员会委员
湖北省肠病中心学术委员会委员
湖北省实验动物专家委员会委员。
目前主要研究领域和兴趣：
本实验室以体细胞、斑马鱼、小鼠和大鼠基因敲除/敲入技术为主要研究方法，从分子水平探讨肿瘤的发病机理, 研究相关基因作用途径和寻找理想的分子靶标，为肿瘤的早期诊断、治疗和预后提供理论依据。
主持课题项目：
1. 项目首席科学家：国家科技支撑计划（2014BAI02B00），2014.07-2017.06
2. 课题组长：国家重大科学研究计划（2011CB944404），2011.01-2015.12
3. 项目负责人：国家自然科学基金面上项目（30971499），2010.01-2012.12
4. 项目负责人：国家自然科学基金面上项目（81270306），2013.01-2016.12
5. 项目负责人：国家自然科学基金面上项目（81470375），2015.01-2018.12
6. 课题骨干：国家科技支撑计划（2012BAI39B03），2012.01-2014.12
教学情况：
分子生物学，本科生课程，3学分
实验室研究技术训练，研究生课程，2学分
细胞生物学研究前沿，研究生课程，2学分
代表论文和著作
X.F. Zhang, K.K. Li, L. Gao, S.Z. Li, K. Chen, J.B. Zhang, D. Wang, R.F. Tu, J.X. Zhang, K.X. Tao, G. Wang,X.D. Zhang,miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta, Oncotarget, 6 (2015) 4144-4158.
Z.Y. Zhang, S.Z. Li, H.H. Zhang, Q.R. Wu, J. Gong, T. Liang, L. Gao, N.N. Xing, W.B. Liu, R.L. Du,X.D. Zhang,Stabilization of ATF5 by TAK1-NLK Critically Regulates the IL-1beta-stimulated C/EBP Signaling Pathway, Mol Cell Biol, (2014).
X.F. Zhang, R. Zhang, L. Huang, P.X. Wang, Y. Zhang, D.S. Jiang, L.H. Zhu, S. Tian,X.D. Zhang,H. Li, TRAF1 is a key mediator for hepatic ischemia/reperfusion injury, Cell death & disease, 5 (2014) e1467.
H.H. Zhang, S.Z. Li, Z.Y. Zhang, X.M. Hu, P.N. Hou, L. Gao, R.L. Du,X.D. Zhang,Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage, Cell death and differentiation, 21 (2014) 1656-1663.
L. Yan, W. Liu, H. Zhang, C. Liu, Y. Shang, Y. Ye,X. Zhang,W. Li, Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery, Journal of cell science, 127 (2014) 1417-1427.
S.Z. Li, H.H. Zhang, J.B. Liang, Y. Song, B.X. Jin, N.N. Xing, G.C. Fan, R.L. Du,X.D. Zhang,Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKbeta, Biochimica et biophysica acta, (2014).
S.-Z. Li, Y. Song, H.-H. Zhang, B.-X. Jin, Y. Liu, W.-B. Liu,X.-D. Zhang,R.-L. Du, UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer, Sci. Rep., 4 (2014).
X.A. Wang, R. Zhang, Z.G. She, X.F. Zhang, D.S. Jiang, T. Wang, L. Gao, W. Deng, S.M. Zhang, L.H. Zhu, S. Guo, K. Chen,X.D. Zhang,D.P. Liu, H. Li, Interferon regulatory factor 3 constrains IKKbeta/NF-kappaB signaling to alleviate hepatic steatosis and insulin resistance, Hepatology, (2013).
L. Wang, Y. Lu, X. Zhang, Y. Zhang, D. Jiang, X. Dong, S. Deng, L. Yang, Y. Guan, L. Zhu, Y. Zhou,X. Zhang,H. Li, Mindin is a critical mediator of ischemic brain injury in an experimental stroke model, Experimental neurology, 247 (2013) 506-516.
S.Z. Li, H.H. Zhang, J.N. Zhang, Z.Y. Zhang, X.F. Zhang,X.D. Zhang,R.L. Du, ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis, Biochemical and biophysical research communications, 437 (2013) 325-330.
D.S. Jiang, X.F. Zhang, L. Gao, J. Zong, H. Zhou, Y. Liu, Y. Zhang, Z.Y. Bian, L.H. Zhu, G.C. Fan,X.D. Zhang, H. Li, Signal Regulatory Protein-alpha Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling, Hypertension, (2013).
Z. Huang, S. Li, W. Song, X. Li, Q. Li, Z. Zhang, Y. Han,X. Zhang,S. Miao, R. Du, L. Wang, Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/Beta-catenin pathway by down-regulating Dickkopf-1 (DKK1), PloS one, 8 (2013) e70077.
K. Chen, L. Gao, Y. Liu, Y. Zhang, D.-S. Jiang, X. Wei, X. Zhu, R. Zhang, Y. Chen, Q. Yang, N. Kioka,X.-D. Zhang,H. Li, Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway, Basic research in cardiology, 108 (2013) 1-14.
Y. Liu, S. Li, H. Zhang, Z. Wan,X. Zhang,R. Du, A one-step cloning method for the construction of somatic cell gene targeting vectors: application to production of human knockout cell lines, BMC biotechnology, 12 (2012) 71.
P. Zhang, Y. Zhao, X. Zhu, D. Sedwick,X. Zhang,Z. Wang, Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis, Molecular cancer research : MCR, 9 (2011) 1418-1428.
R. Du, S. Li,X. Zhang,A modified plasmid vector pCMV-3Tag-LIC for rapid, reliable, ligation-independent cloning of polymerase chain reaction products, Analytical biochemistry, 408 (2011) 357-359.
P. Wang, F. Zou,X. Zhang,H. Li, A. Dulak, R.J. Tomko, Jr., J.S. Lazo, Z. Wang, L. Zhang, J. Yu, microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells, Cancer research, 69 (2009) 8157-8165.
X. Zhang,C. Guo, Y. Chen, H.P. Shulha, M.P. Schnetz, T. LaFramboise, C.F. Bartels, S. Markowitz, Z. Weng, P.C. Scacheri, Z. Wang, Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies, Nature methods, 5 (2008) 163-165.
C. Guo,X. Zhang,S.P. Fink, P. Platzer, K. Wilson, J.K. Willson, Z. Wang, S.D. Markowitz, Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase, Cancer research, 68 (2008) 6118-6126.
X. Zhang,A. Guo, J. Yu, A. Possemato, Y. Chen, W. Zheng, R.D. Polakiewicz, K.W. Kinzler, B. Vogelstein, V.E. Velculescu, Z.J. Wang, Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T, Proceedings of the National Academy of Sciences of the United States of America, 104 (2007) 4060-4064.
