研究方向
发育过程的组织分化与生长调控
研究内容
一直从事组织、器官发育的信号转导调控研究，并在Hippo信号通路、Hh信号通路以及Wg/Wnt等信号通路的调节机制研究中取得过突破性进展，迄今共发表相关研究论文33及综述4篇。2009年回国建立独立实验室以来，主要从事Hippo信号的研究工作，取得了若干突破性进展，以通讯作者或共同通讯作者身份在eLife，PLoS Biol，Cancer Cell，Nat Commun，Cell Res等期刊上发表研究论文17篇及应邀综述2篇，申请共同专利1项。
主要论文
1. Hongling Huang, Shimin Wang, Mengxin Yin,Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu# andLei Zhang# Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association.PLoS Biology2013,11(4) e1001620 (Press released by PLoS Biology)（# corresponding author） 2. Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S. Ho, Hongbin Ji, Yun Zhao#,Lei Zhang# Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling.eLife2013 2: e00999 （# corresponding author） 3. Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#,Lei Zhang# A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.Cell Research2013，23:1201-1214（# corresponding author) 4. Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji#,Lei Zhang#, Zhaocai Zhou#. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer.Cancer Cell2014, 25: 166-180 （# corresponding author) 5. Yijun Gao, Wenjing Zhang, Xiangkun Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun, Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan Chen,Lei Zhang# & Hongbin Ji# YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression.Nat Communications2014, 5:4629 （# corresponding author)
