张欣 （安徽农业大学生命科学学院教授）

人物经历

1993年毕业于吉林大学;

2000年获中国科学院长春应用化学研究所硕士学位；

2002年赴法国留学，在斯特拉斯堡第一大学（路易·巴斯德大学，Université Louis Pasteur, Strasbourg, France）药学院攻读博士学位；

2005年获法国国家博士学位；

2006年6月至2008年9月在美国纽约阿尔伯特·爱因斯坦医学院（Albert Einstein College of Medicine, NY, USA）分子药理系担任研究助理；

2008年底回国；

2009年6月起被聘为安徽农业大学生命科学学院讲席教授。

2023年1月任安徽省第十四届人民代表大会教育科学文化卫生委员会委员

研究方向

主要研究方向为一直从事环境因子对天然产物成分的影响及神经肽的质谱学分析等方面的研究，在有机化学、分析化学、天然产物的分离与分析等基础研究领域具有专长，科研能力强。

主要贡献

发表SCI论文20篇，多项研究成果具有重要的科学价值和应用前景，达到本领域国际先进水平。申请二项中国专利并均已进入公开初审阶段。

科研领域

1. 功能小分子结构及其生理活性的研究：分离制备天然有机功能小分子及其衍生物，研究其化学结构，并运用一系列体内体外模式生物分析相关生理活性，探讨其作用机理。

2.多肽组学研究：开展与植物生理、病理等性状相关的具有生物活性的多肽组学研究。

科研项目

国家自然科学基金项目（21072002）：植物甾醇单体氧化物的制备及其细胞毒性的研究（主持）

教育部留学回国人员科研启动基金（教外司留(2011)1568号）：Δ7-植物甾醇氧化物的合成及生物效应研究（主持）

论文论著

1. Junlan Gao, Qiulin Yue, Yishun Ji, Beijiu Cheng, Xin Zhang*, Novel synthesis strategy for preparation of individual phytosterol oxides,Journal of Agricutural and Food Chemistry, 2013,61, 982-988.

2. Dongqing Cai, Longhai Wang, Xin Zhang*, Zhengyan Wu*, Controlling pesticide loss by natural porous micro/nano composites: straw ash-based biochar and biosilica,ACS Applied Materials & Interfaces, in press.

3. Qiulin Yue, Xiuhong Zhou, Qianli Leng, Lele Zhang, Beijiu Cheng, Xin Zhang*, 7-Ketocholesterol-induced caspase-mediated apoptosis inSaccharomyces cerevisiae,FEMS Yeast Research, accepted.

4. Xin Zhang, Hui Pan, Bonnie Peng, Donald F. Steiner, John E. Pintar, Lloyd D. Fricker, Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis, Journal of Neurochemistry, 2010,112, 1168-1179.

5. Jonathan H. Wardman, Xin Zhang, Sandra Gagnon, Leandro M. Castro, Xiaorong Zhu, Donald F. Steiner, Robert Day, Lloyd D. Fricker, Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics, Journal of Neurochemistry, 2010,114, 215-225.

6. Sebastian Tanco, Xin Zhang, Cain Morano, Francesc X. Avilés, Julia Lorenzo, Lloyd D. Fricker, Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing, Journal of Biological Chemistry, 2010,285, 18385-18396.

7. Denise A. Berti, Cain Morano, Lilian C. Russo, Leandro M. Castro, Fernanda M. Cunha, Xin Zhang, Juan Sironi, Clécio F. Klitzke, Emer S. Ferro, Lloyd D. Fricker, Analysis of intracellular substrates and products of thimet oligopeptidase (EC 3.4.24.15) in human embryonic kidney 293 cells, Journal of Biological Chemistry, 2009,284, 14105-14116.

8. Xin Zhang, Fan-Yun Che, Iryna Berezniuk, Kemal Sonmez, Lawrence Toll, Lloyd D. Fricker, Peptidomics ofCpefat/fat mouse brain regions: Implications for neuropeptide processing, Journal of Neurochemistry, 2008,107, 1596-1613.

9. Cain Morano, Xin Zhang (co-first author), Lloyd D. Fricker, Multiple isotopic labels for quantitative mass spectrometry, Analytical Chemistry, 2008,80, 9298–9309.

10. Fa-yun Che, Xin Zhang, Iryna Berezniuk, Myrasol Callaway, Jihyeon Lim, Lloyd D. Fricker, Optimization of neuropeptide extraction from the mouse hypothalamus, Journal of Proteome Research, 2007,6, 4667-4676.

11. Stamatiki Roussi, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Eric Marchioni, Philippe Geoffroy, Michel Miesch, Francis Raul, Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7β-hydroxysitosterol and 7β-hydroxycholesterol triggered apoptosis in human colon cancer cells, Apoptosis, 2007,12, 87-96.

12. Xin Zhang, Diane Julien-David, Michel Miesch, Francis Raul, Philippe Geoffroy, Dalal Aoudé-Werner, Saïd Ennahar, Eric Marchioni, Quantitative analysis of β-sitosterol oxides in vegetable oils induced by natural sunlight, artificially generated ultraviolet light and irradiation, Journal of Agricutural and Food Chemistry, 2006,54, 5410-5415.

13. Xin Zhang, Amandine Cambrai, Michel Miesch, Stamatiki Roussi, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni, Separation of 5- and 7-phytosterols by adsorption chromatography and semi-preparative RP-HPLC for quantitative analysis of phytosterols in foods, Journal of Agricutural and Food Chemistry, 2006,54, 1196-1202.

14. Stamatiki Roussi, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Philippe Geoffroy, Michel Miesch, Eric Marchioni, Francis Raul, Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7β-hydroxycholesterol and 7β-hydroxysitosterol,International Journal of Oncology, 2006,29, 1549-1554.

15. Xin Zhang, Diane Julien-David, Michel Miesch, Philippe Geoffroy, Francis Raul, Stamatiki Roussi, Dalal Aoudé-Werner, Eric Marchioni, Identification and quantitative analysis of β-sitosterol oxides in vegetable oils by capillary gas chromatography-mass spectrometry, Steroids, 2005,70, 896-906.

16. Xin Zhang, Philippe Geoffroy, Michel Miesch, Diane Julien-David, Francis Raul, Dalal Aoudé-Werner, Eric Marchioni, Gram-scale chromatographic purification of β-sitosterol: Synthesis and characterization of β-sitosterol oxides, Steroids, 2005,70, 886-895.

17. Stamatiki Roussi, Annelise Winter, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Eric Marchioni, Philippe Geoffroy, Michel Miesch, Francis Raul, Different apoptotic mechanisms are involved in the antiproliferative effects of 7β-hydroxysitosterol and 7β-hydroxycholesterol in human colon cancer cells, Cell Death & Differentiation, 2005,12, 128-135