王大勇（海南大学农学院教授）_百科资料

教育背景

2000-09--2003-07沈阳药科大学药理学专业博士

1990-03--1995-01沈阳药科大学英语药学专业学士

工作简历

2013-04--今海南大学农学院生物技术系

2012-05--2013-04美国伊利诺依大学农业、消费者及环境科学学院动物科学系专家 (Research Specialist)

2010-03--2012-05美国伊利诺依大学分子及细胞生物学院分子及整合生理学系研究员 (Research Scientist)

2007-07--2010-02 美国伊利诺依大学分子及细胞生物学院分子及整合生理学系博士后（Postdoctoral Research Associate）

2007-04--2007-06日本名古屋大学医学部杰出中心（Center of Excellency， COE）研究员

2004-10--2007-03 日本（原）公定书协会驻名古屋大学附属医院药剂部研究员（Research Resident）

2002-04--2007-06 日本名古屋大学大学院神经精神药理学系外国人研究员

1995-08-2000-08 哈药集团生物工程有限公司

讲授课程

高级生物化学、生物技术制药、神经生物学

承担的课题

Keap1潜在磷酸化位点及调控信号研究（引进人才科研启动基金资助项目）

发表论文

1. Dayong Wang, Qin Fu, Yuan Zhou, Qian Shi, Benedict Igwe, Elena V. Wisely, Salvatore Oddo, Yang K. Xiang. Amyloid β activates adrenergic receptor to induce intracellular signaling pathways for tau pathology. Journal of Biological Chemistry.2013, 288: 10298-10307.

2. Ruijie Liu, Dayong Wang, Steven Hizon, Qin Fu, Qian Shi, Yang K. Xiang. Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. Plos ONE. 2012, 7(8):1-13.

3. Dayong Wang, Eunice Yuen, Yuan Zhou, Yan Zhen, Yang K. Xiang. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. Journal of Biological Chemistry. 2011, 286(36):31852-63.

4. Dayong Wang, Yang K. Xiang.Chapter 10: β-adrenergic receptor, amyloid Abeta, and Alzheimer’s disease.Current Topics in Membranes: Advances in Adrenergic Receptor Biology. 2011, 67: 205-229.

5. Dayong Wang, G. Govindaiah, Ruijie Liu, Vania De Arcangelis, Charles Lee Cox, Yang K. Xiang. Binding of Amyloid βpeptide to β2adrenergic receptor induces PKA dependent AMPA receptor hyperactivity. The FASEB Journal.2010, 24(9):3511-21.

6. Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshima. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The International Journal of Neuropsychopharmacology. 2010, 13(10):1343-54.

7. Hiroko Tsunekawa, Yukihiro Noda, Masayuki Miyazaki, Fumio Yoneda, Toshitaka Nabeshima, Dayong Wang.Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders.Behavioural Brain Research. 2007, 189(1): 107-116.

8. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Role of N-Methyl-D-aspartate receptors in antidepressant-like effects of σ1 receptor agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride(SA-4503) in olfactory bulbectomized rats. Journal of Pharmacology and Experimental Therapeutics. 2007, 322(3): 1305-1314.

9. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission. Neuropharmacology. 2007,53(3):379-89.

10. Dayong Wang, Yukihiro Noda, Yuan Zhou, Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Weiduo Chen, Toshitaka Nabeshima. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35i.c.v.-injected mice: involvement of dopaminergic systems.Neuropsychopharmacology. 2007, 32(6): 1261-1271.

11. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model. Neuropharmacology. 2007, 52(4):1179-87.

12. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Behavioural and neurochemical features of olfactory bulbectomizedrats resembling depression with comorbid anxiety. Behavioural Brain Research. 2007, 178(2):262-73.

13. 王大勇, 于庆海, 周园, Yukihiro Noda, Toshitaka Nabeshima. 现代免疫佐剂研究. 《中国免疫学杂志》. 2006, 22(2):189-192.

14. Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid {beta} and impairment of learning and memory. Journal of Pharmacology and Experimental Therapeutics. 2006, 317(1):334-40.

15. Dayong Wang, Yukihiro Noda, Toshitaka Nabeshima. Features of olfactory bulbectomized rat model of depression and effects of sigma1 receptor agonist. Japanese Journal of Molecular Psychiatry. 2006, 6(2): 81-84.

16. Akihiro Mouri, Li-Bo Zou, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang,Min-Wei Wang, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioral Brain Research. 2006,168(1):83-91.

17. Takeshi Enomoto, Yukihiro Noda, Akihiro Mouri, Eun-Joo Shin, Dayong Wang, Rina Murai, Kazuo Hotta, Hiroshi Furukawa, Atsumi Nitta, Hyoung-Chun Kim, and Toshitaka Nabeshima. Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-D-aspartate- Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine.Molecular Pharmacology. 2005,68:1765-1774.

18. Hiroko Tsunekawa, Yukihiro Noda, Dayong Wang, Hiroyuki Mouri, Toshitaka Nabeshima. Selegiline potentiates effects of donepezil on cognitive impairment induced by amyloid beta (25-35). Bulletin of the Japanese Society for Neurochemistry. 2005, 44: 182.

19. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Toshitaka Nabeshima and Qinghai Yu. Effects of sodium houtuyfonate on phosphorylation of CaMK II, CREB and ERK 1/2 and expression of c-Fos in macrophages. International Immunopharmacology. 2004, 8: 1083-1088.

20. Tsunekawa Hiroko, Yukihiro Noda, Dayong Wang, Toshitaka Nabeshima. Antidepressive effect of(R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of stress disorders. Journal of Pharmacological Science. 2004, 94 (suppl.): 225P.

21. Dayong Wang, Qinghai Yu, Peggy Eikstadt, Darcy Hammond, Yun Feng, and Na Chen. Studies on adjuvaticity of sodium houttuyfonate and its mechanism. International Immunopharmacology. 2002, 10:1411-1418.

22. Dayong Wang, Qinghai Yu, Yun Feng, and Na Chen. Adjuvanticity of sodium houttuyfonate. Indian Journal of Pharmacology. 2002, 34(5):363-364.