赵炜 （南开大学药学院副教授）

人物经历

1999年7月毕业于山东大学化学系，获化学学士学位；2005年4月毕业于中国科学院生态环境研究中心，获环境化学博士学位（师承孔繁祚研究员），博士研究期间主要从事具有生物活性的寡糖的合成。 2005年3月进入清华大学化学系从事博士后研究工作，从事糖肽的合成及免疫学性质研究，2007年5月出站。2007年6月加入南开大学药学院。2009-2010年在美国俄亥俄州立大学化学与生物化学系作访问学者，并在美国国立卫生院（NIH）Frederick分部做短期交流访问。

现任南开大学药学院副院长。

研究方向

多年从事糖化学和化学生物学领域的科研，在糖苷酶水解抑制剂合成和肿瘤相关糖肽糖蛋白等含糖复合物的合成领域有广泛和深入的研究。

主要贡献

主持或参加过多项国家自然科学基金重点及面上课题和科技部973课题的研究，

论文著作

12. Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang , Lei Li, Jianping Lin, Wei Zhao*, Jing Li*and Peng George Wang*. “Design and synthesis of O-GlcNAcase inhibitors via Click Chemistry and biological evaluations.”Carbohydrate Research. Accepted.

11. Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao* and Peng George Wang *.. “Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136–2144.

10. Yanyan Wang, Srinivas Chalagalla, Tiehai Li, Xue-long Sun, Wei Zhao, Peng G. Wang, Xiangqun Zeng. “Multivalent interaction-based carbohydrate biosensors for signal amplification”. Biosensors and Bioelectronics 26 (2010) 996–1001.

9. Jinhua Wang, Vinh Dang, Wei Zhao, Dongning Lu, Brian K. Rivera, Frederick A. Villamena, Peng George Wang, Periannan Kuppusamy. “Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion”. Bioorganic & Medicinal Chemistry. 18 (2010) 922–929.

8. Yi, Wen; Liu, Xianwei; Xia, Chengfeng; Zhao, Wei; Zhang, Wenpeng; Chen, Xi; Wang, Peng G. “Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering” Proceedings of the National Academy of Sciences, 2009, 106(11), 4207-4212.

7. Wei-Qun Shi, Jia Hu, Wei Zhao, Yan-Mei Li. Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry. Journal of Mass Spectrometry Vol. 41, Issue 9, pp. 1205-1211。

6. Cai, Li; Guan, Wanyi; Wang, Wenjun; Zhao, Wei; Kitaoka, Motomitsu; Shen, Jie; O'Neil, Crystal; Wang, Peng George. “Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.” Bioorganic & Medicinal Chemistry Letters 2009, 19, 5433-5435.

5. Wei Zhao, Fanzuo Kong. Facile synthesis of the heptasaccharide repeating unit of O-deacetylated GXM of C. neoformans serotype B. Bioorganic & Medicinal Chemistry 13 (2005) 121-130.

4. Wei Zhao, Fanzuo Kong. Synthesis of a hexasaccharide fragment of the O-deacetylated GXM of C. neoformans serotype B. Carbohydrate Research. 339 (2004) 1779-1786.

3. Wei Zhao, Guangbin Yang, Fanzuo Kong. Synthesis of two heptasaccharide analogues of the Lentinan repeating unit. Carbohydrate Research. 338 (2003) 2813-2823.

2. Wei Zhao, Fanzuo Kong. Synthesis of Analogues of (1 6)-Branched (1 3)-Glucohexaose. Journal of Carbohydrate Chemistry. Vol. 23, No. 8-9, pp. 453-464, 2004.

1. Wei Zhao, Fanzuo Kong. Synthesis of a heptasaccharide fragment of the O-deacetylated GXM of C. neoformans serotype C. Carbohydrate Research. 340 (2005) 1673-1681.

参编著作

Wei ZHAO, Tiehai LI, and Peng G. WANG. “Enzymatic Synthesis of Complex Carbohydrates”. Comprehensive Natural Products Chemistry II. Volume 6. Elsevier 2010, 5-54.