王进 （西南交通大学教授）

人物经历

1999年毕业于四川大学，获材料学博士学位，现为先进材料技术教育部重点实验室，人工器官表面工程四川省重点实验室研究成员以及材料科学与工程学院教师。现为中国材料研究学会会员，中国生物材料学会会员。曾在香港城市大学物理及材料科学系从事合作研究工作，担任副研究员（Associated Researcher）。

主讲课程

本科教学

本科生：有机化学基础、高分子化学。

硕士研究生：高等高分子化学。

博士研究生：医用高分子材料。

招生信息

1、生物医学工程、材料科学与工程、高分子材料与工程、药学、分子生物学等专业的博士、硕士研究生。

2、生物医学工程本科毕业设计、大学生科研创新训练计划等。

研究方向

主要研究方向为（1）高分子生物材料及表面改性－抗凝血性高分子材料、抗菌性高分子材料表面构建和性能评价，（2）具有药物控制释放功能的高分子材料支架涂层制备与评价的相关研究，（3）等离子体聚合物的制备及生物化构建。

主要贡献

主持项目

主持二项国家自然科学基金项目，一项国家自然科学基金重点项目子项目及新世纪人才基金。作为主要研究人员参加了1项“973”、2项“863”、3项国家自然科学基金项目、1项教育部骨干教师项目，其中作为第一作者在国际、国内重要核心期刊、会议上发表论文70余篇，SCI收录18篇，EI收录13篇，ISTP收录14篇。

科学研究

主持的科研项目有：

1、等离子体聚氧乙烯功能化薄膜的合成及其抗生物粘附特性研究（51173149）60万元，国家自然科学基金（主持），2012.1-2015.12.

2、时序功能性血管支架与植入周围环境的相互作用与调控（81330031）290万元，国家自然科学基金重点项目（主研），2014.1-2018.12.

3、材料诱导干细胞定向分化的微环境及其构建（2011CB606204）184万元，国家重点基础研究发展（973计划）（主研），2011.1-2015.12.

已结题的科研项目：

1、医用金属器械表面具有生物化功能的等离子体聚合薄膜的构建及生物医学行为研究（NCET-07-0715）50万元，教育部新世纪人才支持计划（主持），2008.1-2010.12.

2、介入器械表面等离子体聚合薄膜的抗凝血结构设计与控制（50673081）28万元，国家自然科学基金（主持），2007.1-2009.12.

3、涤纶人工心脏瓣膜缝合环的抗菌表面改性及机理研究（50203011）23万元，国家自然科学基金（主持），2003.1-2005.12.

4、诱导抗凝血生物化表面的设计与构建（2005CB623904）215万元，国家重点基础研究发展计划（973计划）（主研），2005.10-2010.9.

5、抗凝血、抗感染的表面改性新型人工心脏瓣膜（863计划，G19990964706），国家高技术研究发展计划（863计划）（主研），2006.12-2010.12.

6、药物涂层/钛氧薄膜涂层冠状动脉支架技术1000万（主研），项目成果转化， 2007.1-2012.12.

科研团队：

研究小组在本学科学术带头人黄楠教授所领导的研究团队中从事相关工作，本小组主要成员如下：

1、2009级博士生：杨志禄 陈思；

2、2010级博士生：李欣；

3、2011级博士生：罗日方；

4、2012级博士生：刘庆利；

5、2013级博士生张皓；

6、2010级硕士生：李拥虎、陈瑞、吴婧、温煦；

7、2011级硕士生：王鑫、汤淋淋、李小静、钟司；

8、2012级硕士生：刘玉洁、张江、袁书恒；

9、2013级硕士生：申芳瑜、李文君、罗森。

论文著作

论文：2014

(1) Zhilu Yang, Kaiqing Xiong, Pengkai Qi, Ying Yang, Qiufen Tu, Jin Wang*, Nan Huang*, Gallic Acid Tailoring Surface Functionalities of Plasma-Polymerized Allylamine-Coated 316L SS to Selectively Direct Vascular Endothelial and Smooth Muscle Cell Fate for Enhanced Endothelialization. ACS Appl. Mater. Interfaces, 2014, DOI: 10.1021/am405124z,

(2) Si Chen, Xin Li, Zhilu Yang, Shuo Zhou, Rifang Luo, Manfred M. Maitz, Yuancong Zhao, Jin Wang*, Kaiqin Xiong, Nan Huang, A simple one-step modification of various materials for introducing effective multi-functional groups. Colloids and Surfaces B: Biointerfaces, 2014; 113: 125-133.

(3) Si Zhong1, Rifang Luo1, Xin Wang,Linlin Tang, Jian Wu*, Jin Wang*, Runbo Huang, Hongsun, Nan Huang, Colloids and Surfaces B: Biointerfaces, 2014, in press,

2013

(4) Zhilu Yang1, Ying Yang1, Wei Yan, Qiufen Tu, Jin Wang*, Nan Huang, Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules. ACS Appl. Mater. Interfaces, 2013; 5: 10495-10501.

(5) Rifang Luo, Linlin Tang, Si Zhong, Zhilu Yang, Jin Wang*, Yajun Weng, Qiufen Tu, Chongxi Jiang, Nan Huang, In Vitro Investigation of Enhanced Hemocompatibility and Endothelial Cell Proliferation Associated with Quinone-Rich Polydopamine Coating. ACS Appl. Mater. Interfaces, 2013; 5: 1704?1714.

(6) Rifang Luo, Linlin Tang, Jin Wang*, Yuancong Zhao, Qiufen Tu, Yajun Weng, Ru Shen, Nan Huang, Improved immobilization of biomolecules to quinone-rich polydopamine for efficient surface functionalization, Colloids and Surfaces B Biointerfaces. 2013; 106: 66-73.

(7) 陈瑞，刘玉洁，李欣，王进*，孙鸿，黄楠，等离子体类聚氧乙烯薄膜的制备及性能研究. 功能材料, 2013; 44: 3255-3260.

2012

(8) Zhilu Yang, Qiufen Tu, Jin Wang*, Nan Huang*, The role ofheparin binding surfaces in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials, 2012; 33: 6615-6625.

(9) Zhilu Yang, Qiufen Tu, Ying Zhu, Rifang Luo, Xin Li, Yichu Xie, Manfred F. Maitz, Jin Wang*, Nan Huang, Mussel-Inspired Coating of Polydopamine Directs Endothelial and Smooth Muscle Cell Fate for Re-endothelialization of Vascular Devices. Advanced Healthcare Materials, 2012; 1: 548-559.

(10) Zhilu Yang1, Shuo Zhou1, Lei Lu, Xin Wang, Jin Wang*, Nan Huang*, Construction and hemocompatibility study of highly bioactive heparin-functionalized surface, Journal of Biomedical Material Research part A. 2012; 100A: 3124-3133.

(11) Zhilu Yang, Jin Wu, Xin Wang, Jin Wang*, Nan Huang*, Inspired chemistry for a simple but highly effective immobilization of vascular endothelial growth factor on gallic acid-functionalized plasma polymerized film, Plasma Processes and Polymers. 2012; 9: 718-725.

(12) Tingting He, Zhilu Yang, Rui Chen, Jin Wang*, Yongxiang Leng, Hong Sun, Nan Huang, Enhanced endothelialization guided by fibronectin functionalized plasma polymerized acrylic acid film, Materials Science and Engineering: C. 2012; 32: 1025-1032.

(13) Zhilu Yang, Jin Wang*, Xin Li, Qiufen Tu, Hong Sun, Nan Huang, Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films, Applied Surface Science. 2012; 258: 3378-3385.

2011

(14) Zhilu Yang, Qiufen Tu, Jin Wang*, Xingjiang Lei, Tingting He, Hong Sun, Nan Huang. Bioactive Plasma-Polymerized Bipolar Films of Protonated Functionality for Enhanced Endothelial Cellular Mobility. Macromolecular Bioscience. 2011;11:797-805.

(15) Zhilu Yang, Xingjiang Lei, Jin Wang*, Rifang Luo, Tingting He, Hong Sun, Nan Huang. A Novel Technique Toward Bipolar Films Containing Alternating Nano–Layers of Allylamine and Acrylic Acid Plasma Polymers for Biomedical Application. Plasma Processes and Polymers. 2011;8:208-214.

(16) Zhilu Yang, Jin Wang, Rifang Luo, Tingting He, Si Chen, Xingjiang Lei, Hong Sun, Nan Huang. Improved Hemocompatibility Guided by Pulsed Plasma Tailoring the Surface Amino Functionalities of TiO2 Coating for Covalent Immobilization of Heparin. Plasma Processes and Polymers. 2011;8：850-858.

(17) 吴雷刚，吴婧，侯瑞霞，王进*，黄楠. 他克莫司－聚三亚甲基碳酸酯药物洗脱支架涂层研究。功能材料. 2011; 42(11): 1954-1957.

(18) 俞洪飞，赵元聪，王进*. 磷酸胆碱表面改性涤纶材料及抗凝血性研究. 功能材料. 2011; 42(7): 1265-1268.

2010

(19) Zhilu Yang, Jin Wang, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072-2083.

(20) Xiaona Wang, Jin Wang, Zhilu Yang, Yongxiang Leng, Hong Sun, Nan Huang. Structural characterization and mechanical properties of functionalized pulsed-plasma polymerized allylamine film. Surface and Coatings Technology, 2010; 204(18-19): 3047-3052.

(21) Xiaoqing Xue, Jin Wang*, Ying Zhu, Qiufen Tu, Nan Huang. Biocompatibility of pure titanium modified by human endothelial cell-derived extracellular matrix. Applied Surface Science, 2010; 256: 3866-3873.

(22) Ruixia Hou, Leigang Wu, Jin Wang*, Nan Huang. Investigation on biological properties of tacrolimus-loaded poly(1,3-trimethylene carbonate) in vitro. Applied Surface Science, 2010; 256: 5000-5005.

2004-2009

(23) Zhilu Yang, Xiaona Wang, Jin Wang*, Ye Yao, Hong Sun, Nan Huang. Pulsed-Plasma Polymeric Allylamine Thin Films. Plasma Processes and Polymers. 2009;6:498-505.

(24) 左文瑾，王进，杨志禄，孙鸿，黄楠，聚乙烯吡咯烷酮等离子体接枝改性聚丙烯的亲水性及抗凝血性研究. 功能材料. 2009; 40: 667-669, 673.

(25) Ren Jingrun, Wang Jin*, Sun Hong, Huang Nan. Surface modification of polyethylene terephthalate with albumin and gelatin for improvement of anticoagulation and endothelialization. Applied Surface Science, 2008; 255: 263-266.

(26) 杨志禄，王进*，孙鸿，陈俊英，黄楠. 等离子体聚合沉积聚烯丙胺薄膜改性聚酯及体外血小板黏附研究. 功能材料. 2008; 39(9): 1559-1561, 1566.

(27) 任玲，王进*，唐家驹，潘长江，黄楠. 含姜黄素的（丙交酯－乙交酯）共聚物薄膜对血管平滑肌细胞增殖的影响. 生物医学工程学杂志. 2008; 25( 4): 874-877.

(28) 王海波，王进*，王晓娜，孙鸿，黄楠，等离子体聚合薄膜改性医用不锈钢及内皮细胞黏附行为研究。功能材料. 2008; 39(7): 1193-1196.

(29) 唐家驹，王进*，潘长江，任玲，黄楠。姜黄素/聚乳酸—乙醇酸共聚物复合薄膜的制备及抗凝血研究. 生物医学工程学杂志. 2008; 25(1): 113-116.

(30) 闫峰，王进，杨志禄，张钊，孙鸿，黄楠.白蛋白固定等离子体聚烯丙胺薄膜及体外血小板粘附行为. 生物医学工程研究. 2008; 27(4): 268-271.

(31) J. X. Li, J. Wang*, L. R. Shen, Z. J. Xu, P. Li, G. J. Wan, N. Huang. The influence of polyethylene terephthalate surfaces modified by silver ion implantation on bacterial adhesion behavior. Surface & Coatings Technology, 2007; 201: 8155-8159.

(32) 侯瑞霞，翁亚军，王进*，王志浩，冷永祥，黄楠. Ti-O－N表面肝素分子的共价固定及抗凝血性研究。无机材料学报, 2007; 22(5): 996-1000.

(33) Jin Wang, Jianxin Li, Ling Ren, Ansha Zhao, Peng Li, Yongxiang Leng, Hong Sun, Nan Huang. Antibacterial activity of silver surface modified polyethylene terephthalate by filtered cathodic vacuum arc method, Surf. Coat. Tech.. 2007; 201: 6893-6896.

(34) Wang Jin, Li Jianxin, Shen Liru, Ren Ling, Xu Zejin, Zhao Ansha, Leng Yongxiang, Huang Nan. The biomedical properties of polyethylene terephthalate surface modified by silver ion implantation, Nuclear Instruments Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2007; 257: 141-1456.

(35) J. Wang, J.Y. Chen, P. Yang, Y.X. Lenga, G.J. Wan, H. Sun, A.S. Zhao, N. Huang, P.K. Chu. vitro platelet adhesion and activation of polyethylene terephthalate modified by acetylene plasma immersion ion implantation and deposition. Nuclear Instruments and Methods in Physics Research Section BBeam Interactions with Materials and Atoms. 2007; 242:12-14.

(36) Wang Jin, Tang Jiaju, Ren ling, Pan Changjiang, Huang Nan, Effect of rapamycin/curcumin co-loaded poly(Lactide-Co-Glycolide) films on blood compatibility and vascular smooth muscle cell proliferation. Key Engineering Materials. 2007; 342-343: 317-320.

(37) Tang Jiaju, Wang Jin*, Pan Changjiang, Weng Yajun, Huang Nan, Anticoagulation and drug release behavior of curcumin-loaded PLGA films. Key Engineering Materials. 2007; 342-343: 481-484.

(38) L. Ren, J. Wang*, J.J. Tang, Ch.J. Pang, M. Maitz, N. Huang, Biological evaluation of sirolimus-loaded PLGA films. Key Engineering Materials. 2007; 342-343:837-840.

(39) Jianxin Li, Jin Wang,* Peng Li, Yajun Weng, Ling Ren, Xueling Fei,Hong Sun, Nan Huang, Ozone-induced immobilization of chitosan and heparin on polyethylene terephthalate films to improve antithrombogenic properties. Key Engineering Materials. 2007; 342-343:809-812.

(40) J. Wang, J.Y. Chen, P. Yang, Y.X. Lenga, G.J. Wan, H. Sun, A.S. Zhao, N. Huang, P.K. Chu. In vitro platelet adhesion and activation of polyethylene terephthalate modified by acetylene plasma immersion ion implantation and deposition. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2006; 242:12-14.

(41) 王进，潘长江，李鹏，冷永祥，陈俊英，万国江，杨苹，孙鸿，黄楠. 医用涤纶材料表面类金刚石涂层的表面自由能参数对细菌粘附的影响. 生物医学工程学杂志. 2006; 23(2): 342-345.

(42) 李建新，王进*，沈丽如，许泽金，陈燕，李鹏，黄楠. 银离子注入表面改性涤纶材料的抗菌性能研究. 真空科学与技术学报. 2006; 26(5): 408-411.

(43) 唐家驹，潘长江，洪玮，王进*，黄楠. 大黄素/聚乳酸物复合薄膜的制备及抗凝血研究. 功能材料. 2006; 37(8): 1312-1313, 1317.

(44) Wang, J., Pan C.J., Huang, N., Sun, H., Yang, P., Leng, Y.X., Chen, J.Y., Wan, G.J., Chu, P.K., Surface characterization and blood compatibility of poly(ethylene terephthalate) modified by plasma surface grafting.Surface & Coatings Technology.2005; 196: 307-11.

(45) Wang J., Li P., Sun H., Yang P., Leng Y. X., Chen J.Y., Huang N.. Blood Compatibility of Chitosan Immobilized on Poly(Ethylene Terephthalate) Surface Modified by Plasma and Ultraviolet Grafting. Key Engineering Materials. 2005; 288-289: 327-330.

(46) 王进，Kwok S.C.H.，陈俊英，杨萍，黄楠，Chu P. K..磷掺杂类金刚石薄膜的制备与性能研究。真空科学与技术学报. 2005; 25(2):123-126.

(47) Wang J., Huan, N., Yang P., Leng Y.X., Sun H., Liu Z.Y., Chu, P.K.. The effects of amorphous carbon films deposited on polyethylene terephthalate on bacterial adhesion. Biomaterials. 2004; 25: 3163-70.

(48) Wang J., Huang, N., Pan, C.J., Kwok, S.C.H., Yang, P., Leng, Y.X., Chen, J.Y., Sun H., Wan G.J., Liu Z.Y., Chu P.K.. Bacterial repellence from polyethylene terephthalate surface modified by acetylene plasma immersion ion implantation-deposition. Surface & Coatings Technology. 2004; 186: 299-304.

(49) Wang J., Pan C.J., Kwok S.C.H., Yang P., Chen J.Y., Wan G.J., Huang N., Chu P.K.. Characteristics and anticoagulation behavior of polyethylene terephthalate modified by C2H2 plasma immersion ion implantation-deposition. Journal of Vacuum Science & Technology A (Vacuum, Surfaces, and Films). 2004; 22: 170-5.

授权发明专利

1. 王进，杨志禄，黄楠，冷永祥，赵元聪，一种具有高生物功能性的肝素化界面材料制备方法，中国发明专利ZL201110195704.5，授权时间2013年7月31日；

2. 王进，杨志禄，冷永祥，孙鸿，黄楠，基于类聚乙二醇的可回收下腔静脉滤器表面膜制备方法，中国发明专利ZL201110277736.X，授权时间2013年6月12日；

3. 王进，黄楠，杨苹，孙鸿，冷永祥，陈俊英，万国江，赵安莎，游天雪，吴熹，一种具有抗菌功能的人工心脏瓣膜缝合环涤纶材料，中国发明专利ZL200810046050.8，授权日2011年12月；

4. 黄楠，侯瑞霞，王进，吴雷刚，一种具有防再狭窄涂层的血管支架及其制备方法，2012.5，中国发明专利ZL200910216008.0，授权日2012年5月。

专业著作

黄楠，王进译《生物材料科学：医用材料导论》（顾中伟，刘伟、俞耀庭等译校）第7章第3节--- “心血管医疗器械”，科学出版社，2011.06。

获奖记录

1、 2013年获批四川省有突出贡献的优秀专家；

2、四川省科技进步一等奖（2007，排名第五）：钛基抗凝血薄膜材料研究；

3、 2007年入选教育部新世纪人才培养计划。