王平 （华东师范大学生命医学研究所PI）

人物经历

1997年毕业于复旦大学生命科学学院生物系，获理学学士学位；

2002年7月毕业于中科院上海细胞与生化研究所，获分子细胞生物学博士学位；

2003年到2008年先后在美国明尼苏达大学、康地涅克大学及耶鲁大学药学系做博士后研究。

2008年7月受聘于华东师范大学，任教授及博士生导师。

主要贡献

科研方向

细胞信号传导

(1) 炎症信号传导：炎性细胞如中性粒细胞发生定向迁移的分子机制；血管内皮细胞在炎症发生中的作用及调控机制；炎症过程中白细胞与血管内皮细胞黏附的分子机制；炎症相关重大疾病。

(2) 肿瘤信号传导：肿瘤发生发展及转移中的重要调控蛋白（如AKT/Myc/PTEN/KLFs等）的翻译后修饰如泛素化及类泛素化、磷酸化及乙酰化以及与肿瘤发生的关系。

(3)干细胞信号传导：干细胞干性维持及分化过程中关键蛋白的翻译后修饰如泛素化、磷酸化及乙酰化调控。

科研项目

科研论文

1. Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P.Ubiquitin-Specific Protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration. Biochem. J.(2012) 441,979-986

2. Wang Q, Xu X, Li J, Liu J, Gu H, Zhang R, Chen J, Kuang Y, Fei J, Jiang C, Wang P, Pei D, Ding S, Xie X. Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 2011 Jul 5. doi: 10.1038/cr.2011.108.

3. Wenwen Xu *,Ping Wang *#, Bj?rn Petri, Yong Zhang, Wenwen Tang, Le Sun, Holger Kress, Tom Mann, Yan Shi, Paul Kubes & Dianqing Wu#. Important Roles of PIP5K1C in Neutrophil RecruitmentImmunity2010 33(3): 340-50 (Co-corresponding author)

4. Li C, Yang Z, Li Z, Ma Y, Zhang L, Zheng C, Qiu W, Wu X, Wang X, Li H, Tang J, Qian M, Li D,Wang P, Luo J, Liu M. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-kappaB and MAPK signaling pathways.J Bone Miner Res.2010 Sep 2.

5. Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, Wang Y, Wang W, Wang R, Wang Q, Sun J,Wang P. The Fbw7/hCDC4 tumor suppressor targets pro-proliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs.J Biol Chem.2010 285(24):18858-67. (Corresponding author)

6. Wang Z, Kumamoto Y,Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.J Biol Chem.2009 Oct 16; 284(42):28599-606.

7. Wang Z, Liu B,Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.J Clin Invest.2008 Jan 2;118(1):195-204

8.Ping Wang, Jing Nie and Duanqing Pei. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen.J Biol Chem.2004 Dec 3;279(49):51148-51155，

9.Ping Wang, Xing Wang and Duanqing Pei. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV.J Biol Chem.2004 May 7;279 (19):20461-20470.

10.Ping Wang, Tortorella M, England K, Malfait AM, Thomas G, Arner L, Pei D. Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network.J Biol Chem. 2004, April 9, 279(15):15434-15440.

11.Ping Wang*, Hua Gao*, Yanxiang Ni, Beibei Wang, Yalan Wu, Linhua Qin, Lan Ma, Gang Pei. b-arrestin 2 functions as a GPCR-activated regulator of oncoprotein Mdm2.J Biol Chem.2003 Feb 21; 278(8):6363-6370.

12.Ping Wang,Ya-Lan Wu, Xin Ge, and Gang Pei. Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus.J Biol Chem. 2003 Mar 28;278(13):11648-11653.

13.Ping Wang*, Ya-Lan Wu*, Tian-Hua Zhou, Yue Sun and Gang Pei (2000), Identification of alternative splicing variants of the b subunit of human Ca/calmodulin-dependent protein kinase II with different activities.FEBS Letters475 (2000) 107-110.

14. Kun Ling*,Ping Wang*, Jian Zhao*, Ya-Lan Wu, Zhijie Cheng, Guo-Xiang Wu, Wei Hu, Lan Ma and Gang Pei. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors.Proc. Natl. Acad. Sci. USA.1999 July. 96: 7922-7927.

15. Jian Qiu,Ping Wang, Qing Jing, Wenbo Zhang, Xiaoyu Li, Yongping Zhong, Gang Sun, Gang Pei and Yizhang Chen. (2001) Rapid Activation of ERK1/2 Mitogen-Activated Protein Kinase by Corticosterone in PC12 Cells.Biochemical and Biophysical Research Communications287, 1017–1024.

16. Liguang Lou, Tianhua Zhou,Ping Wang, and Gang Pei. (1999). Modulation of Ca /Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of alpha and beta Isoforms.Molecular Pharmacology, 1999, 55:557–563.

17. Qing Jing, Sun-Mei Xin, Wen-Bo Zhang,Ping Wang, Yong-Wen Qin, Gang Pei.( 2000). Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis.Circ Res. 2000;87:52-59.)

18. Jian Zhao, Lan Ma, Ya-lan Wu,Ping Wang, Wei Hu and Gang Pei (1998). Chemokine Receptor CCR5 functionally couples to inhibitory G protein and undergoes desensitization.Journal of Cellular Biochemistry 1998, 71:36-45. * co-first author

获奖记录

1. 2012年 基金委优秀青年基金计划支出；

2. 2011年 上海市‘曙光学者’人才计划；

3. 2010年 教育部新世纪人才计划；

4. 2009年 上海市‘青年科技启明星’人才计划；

5. 2006年 AHA Postdoctoral fellowship；

6. 2000年 中科院地奥奖学金；

7. 1999年 中科院伟华奖学金。