刘忠 （暨南大学副研究员硕导）

人物经历

学习经历：　2003-2008，博士学位，中山大学（2003-2005）/香港理工大学（2005-2008）。

1999-2003，学士学位，中山大学。

工作经历：

2009至今：暨南大学生命科学技术学院/ 生物医药研究院/ 生物医药研究开发基地。

主讲课程

《高等生物化学》，《细胞信号传导与技术》，《生物信息学》。

研究方向

1. 细胞生物学及化学生物学：靶向抗肿瘤、抗病毒药物研发及药物作用机制。

2. 生物信息学及化学信息学：基于重要疾病靶标的计算机辅助药物设计与应用，药物虚拟筛选，蛋白质结构预测及分子相互作用预测，生物信息数据分析，量子化学计算。

主要贡献

承担课题

1.国家自然科学基金青年科学基金项目，基于靶标TrxR 的新型曼宋酮F类似物的抗宫颈癌活性作用机制研究，主持

2.广东省自然科学基金博士启动项目，基于靶标TrxR的新型Mansonone F类似物抗宫颈癌作用机制研究，主持

3. 广东高校优秀青年创新人才培养计划（育苗工程）项目（LYM10029），主持

4. 广州市科技计划应用基础研究重点项目，基于Akt信号通路的新型Hsp90抑制剂逆转白血病细胞多药耐药的作用机制研究，主持

5. 天然药物及仿生药物国家重点实验室开放课题，南药余甘子中没食子酰基多酚成分诱导自噬抗I型疱疹病毒的作用机制与构效关系研究，主持

6.暨南大学引进优秀人才科研启动基金，硫氧还蛋白还原酶靶向小分子抑制剂抗肿瘤机制研究，主持

7. 十二五国家科技支撑计划子课题，基于南药小分子化合物的抗单纯疱疹病毒药靶发现，参与

主要论文

1. Wang SX, Ju HQ, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z*, Wang YF*. SNX -2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells. Biosci Biotech Bioch. 2011, 75(8): 1540-1545.

2. Liu JY*, Liu Z*, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF, Yang DP. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011, 190(2-3): 91-101. (*, co-first author)

3. Liu Z, Huang SL, Li MM, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by mansonone F analogues: implications for anticancer activity. Chem Biol Interact. 2009, 177(1): 48-57.

4. Liu Z, Du ZY, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by curcumin analogs. Biosci Biotech Bioch. 2008, 72(8): 2214-2218.

5. Qiu X*, Liu Z*, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ, Huang ZS, Gu LQ. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors. Bioorg Med Chem. 2008, 16(17): 8035-8041. (*, co-first author)

6. Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C. Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete. Org Lett, 2012, 14 (13), 3364–3367.

7. He F, Liu Z, Yang J, Fu P, Peng J, Zhu WM, Qi SH. A novel antifouling alkaloid from halotolerant fungus Penicillium sp. OUCMDZ-776, Tetrahedron Lett. 2012, 53(18): 2280-2283.

8. Li MM, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL, Ye WC. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012, 83(9): 1251-1260.

9. Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncol Rep. 2012, 27(6):1904-1910.

10. Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX, Wang YF. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett. 2012, 318(2): 66-74.

11. Zhang XQ, Xu FF, Wang L, Huang MY, Liu Z, Zhang DM, Wang GC, Li YL, Ye WC, Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem Lett. 2012, 5(2): 292-296.

12. Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A, Zhang L. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 2012, DOI: 10.1021/np300221a

13. Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, Wang YF. Preclinical pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomed Pharmacother. 2011, 65(2): 132-136.

14. Sun F, Liu JY, He F, Liu Z, Wang R, Wang DM, Wang YF, Yang DP. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011, 13(8): 688-699.

15. Ju HQ, Wang SX, Xiang YF, Liu Z, Liu JY, Chen ZP, Zeng FL, Xia M, Liu ZH, Xing GW, Wang SY, Wang YF. BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur J Pharmacol. 2011, 666: 26-34.

16. Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Org Lett. 2010, 12(21):5040-5043.

17. Zhou GX, Mo SY, He HX, Shi JG, Ye WC, Liu Z. Jiang RW, Molecular structure and tautomerization of the 1:1 complex of luteoskyrin and rugulosin J Mol Struct. 2010, 979(1): 86-91.

18. Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC. Bufogargarizins A and B two novel 19-norbufadienolides with unprecedented skeletons from the venom of bufo bufo gargarizans. Chem Eur J. 2010, 16(36): 10989-10993.

19. Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, Wang YF. Determination of SNX-2112, a selective Hsp90 inhibitor in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. J Pharm Biomed Anal. 2010, 53(4): 1048-1052.